• Bzdok et al., 2015
    Subspecialization in the human posterior medial cortex
    Neuroimage106: 55-71.
    D. Bzdok, A. Heeger, R. Langner, A. Laird, P. Fox, N. Palomero-Gallagher, B. Vogt, K. Zilles, S. Eickhoff

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    ABSTRACT: The posterior medial cortex (PMC) is particularly poorly understood. Its neural activity changes have been related to highly disparate mental processes. We therefore investigated PMC properties with a data-driven exploratory approach. First, we subdivided the PMC by whole-brain coactivation profiles. Second, functional connectivity of the ensuing PMC regions was compared by task-constrained meta-analytic coactivation mapping (MACM) and task-unconstrained resting-state correlations (RSFC). Third, PMC regions were functionally described by for- ward/reverse functional inference. A precuneal cluster was mostly connected to the intraparietal sulcus, frontal eye fields, and right temporo-parietal junction; associated with attention and motor tasks. A ventral posterior cingulate cortex (PCC) cluster was mostly connected to the ventromedial prefrontal cortex and middle left infe- rior parietal cortex (IPC); associated with facial appraisal and language tasks. A dorsal PCC cluster was mostly connected to the dorsomedial prefrontal cortex, anterior/posterior IPC, posterior midcingulate cortex, and left dorsolateral prefrontal cortex; associated with delay discounting. A cluster in the retrosplenial cortex was mostly connected to the anterior thalamus and hippocampus. Furthermore, all PMC clusters were congruently coupled with the default mode network according to task-unconstrained but not task-constrained connectivity. We thus identified distinct regions in the PMC and characterized their neural networks and functional implications.
    Keywords: Connectivity-based parcellation -- Statistical learning -- Functional decoding -- Parietal lobe -- Posterior cingulate cortex -- Retrosplenial cortex -- Default mode network
    Submitted by: danilo
    Current version: 1
    Last modified: 2016-02-26 17:18:14
    Redistributable: true
    ANIMA ID: 576393

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